|Producer||United States National Library of Medicine (United States)|
|History||2000 to present|
|Record depth||Index, abstract & full-text|
|Format coverage||Journal articles|
PubMed Central (PMC) is a free digital repository that archives open access full-text scholarly articles that have been published in biomedical and life sciences journals. As one of the major research databases developed by the National Center for Biotechnology Information (NCBI), PubMed Central is more than a document repository. Submissions to PMC are indexed and formatted for enhanced metadata, medical ontology, and unique identifiers which enrich the XML structured data for each article.  Content within PMC can be linked to other NCBI databases and accessed via Entrez search and retrieval systems, further enhancing the public's ability to discover, read and build upon its biomedical knowledge. 
PubMed Central is distinct from PubMed.  PubMed Central is a free digital archive of full articles, accessible to anyone from anywhere via a web browser (with varying provisions for reuse). Conversely, although PubMed is a searchable database of biomedical citations and abstracts, the full-text article resides elsewhere (in print or online, free or behind a subscriber paywall).
As of December 2018 [update], the PMC archive contained over 5.2 million articles,  with contributions coming from publishers or authors depositing their manuscripts into the repository per the NIH Public Access Policy. Earlier data shows that from January 2013 to January 2014 author-initiated deposits exceeded 103,000 papers during a 12-month period.  PMC identifies about 4,000 journals which participate in some capacity to deposit their published content into the PMC repository.  Some publishers delay the release of their articles on PubMed Central for a set time after publication, referred to as an "embargo period", ranging from a few months to a few years depending on the journal. (Embargoes of six to twelve months are the most common.) PubMed Central is a key example of "systematic external distribution by a third party",  which is still prohibited by the contributor agreements of many publishers.
Launched in February 2000, the repository has grown rapidly as the NIH Public Access Policy is designed to make all research funded by the National Institutes of Health (NIH) freely accessible to anyone, and, in addition, many publishers are working cooperatively with the NIH to provide free access to their works. In late 2007, the Consolidated Appropriations Act of 2008 (H.R. 2764) was signed into law and included a provision requiring the NIH to modify its policies and require inclusion into PubMed Central complete electronic copies of their peer-reviewed research and findings from NIH-funded research. These articles are required to be included within 12 months of publication. This is the first time the US government has required an agency to provide open access to research and is an evolution from the 2005 policy, in which the NIH asked researchers to voluntarily add their research to PubMed Central. 
A UK version of the PubMed Central system, UK PubMed Central (UKPMC), has been developed by the Wellcome Trust and the British Library as part of a nine-strong group of UK research funders. This system went live in January 2007. On 1 November 2012, it became Europe PubMed Central. The Canadian member of the PubMed Central International network, PubMed Central Canada, was launched in October 2009.
The National Library of Medicine "NLM Journal Publishing Tag Set" journal article markup language is freely available.  The Association of Learned and Professional Society Publishers comments that "it is likely to become the standard for preparing scholarly content for both books and journals".  A related DTD is available for books.  The Library of Congress and the British Library have announced support for the NLM DTD.  It has also been popular with journal service providers. 
With the release of public access plans for many agencies beyond NIH, PMC is in the process of becoming the repository for a wider variety of articles.  This includes NASA content, with the interface branded as "PubSpace".  
Articles are sent to PubMed Central by publishers in XML or SGML, using a variety of article DTDs. Older and larger publishers may have their own established in-house DTDs, but many publishers use the NLM Journal Publishing DTD (see above).
Received articles are converted via XSLT to the very similar NLM Archiving and Interchange DTD. This process may reveal errors that are reported back to the publisher for correction. Graphics are also converted to standard formats and sizes. The original and converted forms are archived. The converted form is moved into a relational database, along with associated files for graphics, multimedia, or other associated data. Many publishers also provide PDF of their articles, and these are made available without change. 
Bibliographic citations are parsed and automatically linked to the relevant abstracts in PubMed, articles in PubMed Central, and resources on publishers' Web sites. PubMed links also lead to PubMed Central. Unresolvable references, such as to journals or particular articles not yet available at one of these sources, are tracked in the database and automatically come "live" when the resources become available.
An in-house indexing system provides search capability, and is aware of biological and medical terminology, such as generic vs. proprietary drug names, and alternate names for organisms, diseases and anatomical parts.
When a user accesses a journal issue, a table of contents is automatically generated by retrieving all articles, letters, editorials, etc. for that issue. When an actual item such as an article is reached, PubMed Central converts the NLM markup to HTML for delivery, and provides links to related data objects. This is feasible because the variety of incoming data has first been converted to standard DTDs and graphic formats.
In a separate submission stream, NIH-funded authors may deposit articles into PubMed Central using the NIH Manuscript Submission (NIHMS). Articles thus submitted typically go through XML markup in order to be converted to NLM DTD.
Reactions to PubMed Central among the scholarly publishing community range between a genuine enthusiasm by some,  to cautious concern by others. 
While PMC is a welcome partner to open access publishers in its ability to augment the discovery and dissemination of biomedical knowledge, that same truth causes others to worry about traffic being diverted from the published version of record, the economic consequences of less readership, as well as the effect on maintaining a community of scholars within learned societies.   A 2013 analysis found strong evidence that public repositories of published articles were responsible for "drawing significant numbers of readers away from journal websites" and that "the effect of PMC is growing over time". 
Libraries, universities, open access supporters, consumer health advocacy groups, and patient rights organizations have applauded PubMed Central, and hope to see similar public access repositories developed by other federal funding agencies so to freely share any research publications that were the result of taxpayer support. 
The Antelman study of open access publishing found that in philosophy, political science, electrical and electronic engineering and mathematics, open access papers had a greater research impact.  A randomised trial found an increase in content downloads of open access papers, with no citation advantage over subscription access one year after publication. 
The NIH policy and open access repository work has inspired a 2013 presidential directive which has sparked action in other federal agencies as well.
In March 2020, PubMed Central accelerated its deposit procedures for the full text of publications on coronavirus. The NLM did so upon request from the White House Office of Science and Technology Policy and international scientists to improve access for scientists, healthcare providers, data mining innovators, AI healthcare researchers, and the general public. 
The PMCID (PubMed Central identifier), also known as the PMC reference number, is a bibliographic identifier for the PubMed Central open access database, much like the PMID is the bibliographic identifier for the PubMed database. The two identifiers are distinct however. It consists of "PMC" followed by a string of seven numbers. The format is: 
Authors applying for NIH awards must include the PMCID in their application.
To support this initiative, NLM is adapting its standard procedures for depositing articles into PMC to provide greater flexibility that will ensure coronavirus research is readily available.
[[Category:Open-ac cess archives]]